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Tricyclic Antidepressants


Tricyclic Antidepressants/Nutrient Depletion:
  • Coenzyme Q10Coenzyme Q10: According to secondary sources, antidepressants may reduce the natural production of CoQ10. Use of both agents, therefore, may result in diminished effects of CoQ10. Specific medications noted in anecdotal reports include amitripyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, nortriptyline, and perphenazine.
  • RiboflavinRiboflavin: Based on animal studies, tricyclic antidepressants, such as imipramine, desimpramine, amitriptyline, and nortriptyline, may reduce levels of riboflavin in the body, possibly meriting supplementation (6262379).

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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.

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